FERM domain

FERM N-terminal domain
crystal structure of the ferm domain of merlin, the neurofibromatosis 2 tumor suppressor protein.
Identifiers
SymbolFERM_N
PfamPF09379
Pfam clanCL0072
InterProIPR018979
SCOP21gc7 / SCOPe / SUPFAM
OPM superfamily49
OPM protein1gc6
Membranome161
Available protein structures:
PDB  IPR018979 PF09379 (ECOD; PDBsum)  
AlphaFold
FERM central domain
crystal structure of the protein 4.1r membrane binding domain
Identifiers
SymbolFERM_M
PfamPF00373
InterProIPR019748
SCOP21gc7 / SCOPe / SUPFAM
CDDcd14473
Available protein structures:
PDB  IPR019748 PF00373 (ECOD; PDBsum)  
AlphaFold
FERM C-terminal PH-like domain
crystal structure of the radixin ferm domain complexed with the nep cytoplasmic tail
Identifiers
SymbolFERM_C
PfamPF09380
Pfam clanCL0266
InterProIPR018980
SCOP21ef1 / SCOPe / SUPFAM
CDDcd00836
Available protein structures:
PDB  IPR018980 PF09380 (ECOD; PDBsum)  
AlphaFold

In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found.

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