FBXW7

FBXW7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OVP, 2OVQ, 2OVR, 5IBK
Identifiers
Aliases	FBXW7, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7
External IDs	OMIM: 606278; MGI: 1354695; HomoloGene: 117451; GeneCards: FBXW7; OMA:FBXW7 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	152,536,092 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	84,886,505 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; Achilles tendon; ; epithelium of colon; ; middle temporal gyrus; ; superior frontal gyrus; ; occipital lobe; ; pons; ; parietal lobe; ; primary visual cortex; ; postcentral gyrus;
	Top expressed in
	prefrontal cortex; ; primary motor cortex; ; barrel cortex; ; visual cortex; ; temporal lobe; ; primary visual cortex; ; amygdala; ; saccule; ; superior frontal gyrus; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding; ubiquitin-protein transferase activator activity; identical protein binding; ubiquitin protein ligase binding; cyclin binding; phosphothreonine residue binding; ubiquitin-protein transferase activity; ubiquitin binding;
Cellular component	cytoplasm; Parkin-FBXW7-Cul1 ubiquitin ligase complex; SCF ubiquitin ligase complex; nucleoplasm; nucleolus; nucleus; cytosol; mitochondrion; endoplasmic reticulum; Golgi apparatus; perinuclear region of cytoplasm;
Biological process	positive regulation of epidermal growth factor-activated receptor activity; positive regulation of protein targeting to mitochondrion; negative regulation of SREBP signaling pathway; cellular response to UV; negative regulation of triglyceride biosynthetic process; protein stabilization; negative regulation of hepatocyte proliferation; sister chromatid cohesion; cellular response to DNA damage stimulus; regulation of protein localization; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; vasculature development; regulation of autophagy of mitochondrion; negative regulation of DNA endoreduplication; positive regulation of ubiquitin-protein transferase activity; positive regulation of ubiquitin-dependent protein catabolic process; protein ubiquitination; lipid homeostasis; positive regulation of ERK1 and ERK2 cascade; regulation of cell cycle G1/S phase transition; regulation of lipid storage; viral process; positive regulation of proteasomal protein catabolic process; positive regulation of protein ubiquitination; negative regulation of Notch signaling pathway; protein polyubiquitination; post-translational protein modification; negative regulation of osteoclast development; vasculogenesis; Notch signaling pathway; negative regulation of gene expression; ubiquitin recycling; lung development; protein destabilization; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of cell migration involved in sprouting angiogenesis; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	55294
	50754
	ENSG00000109670
	ENSMUSG00000028086
	Q969H0
	Q8VBV4
	NM_001013415; NM_001257069; NM_018315; NM_033632; NM_001349798
	NM_001177773; NM_001177774; NM_080428
	NP_001013433; NP_001243998; NP_060785; NP_361014; NP_001336727
	NP_001171244; NP_001171245; NP_536353
	Wikidata
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F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene.