Estradiol 3-tetrahydropyranyl ether

Estradiol 3-tetrahydropyranyl ether
Clinical data
Other names	NSC-86473; Estra-1,3,5(10)-triene-17β-diol 3-(tetrahydropyran-2-yl) ether; 3-(Tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-3-ol
Routes of; administration	By mouth
Drug class	Estrogen; Estrogen ether
Identifiers
	IUPAC name (8R,9S,13S,14S,17S)-13-Methyl-3-(oxan-2-yloxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol;
CAS Number	41781-86-6 ;
PubChem CID	257864;
ChemSpider	226239;
UNII	2UC9XAN8CV;
ChEMBL	ChEMBL472508;
Chemical and physical data
Formula	C23H32O3
Molar mass	356.506 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC5CCCCO5;
	InChI InChI=1S/C23H32O3/c1-23-12-11-18-17-8-6-16(26-22-4-2-3-13-25-22)14-15(17)5-7-19(18)20(23)9-10-21(23)24/h6,8,14,18-22,24H,2-5,7,9-13H2,1H3/t18-,19-,20+,21+,22?,23+/m1/s1; Key:BOLMNLJKDBCJIB-CUFSGNDSSA-N;

Estradiol 3-tetrahydropyranyl ether is a synthetic estrogen and estrogen ether which was never marketed. It has been reported to possess improved oral activity relative to estradiol. One study in animals found that it had 15 times the oral activity of estradiol.