Estradiol 17β-tetrahydropyranyl ether

Estradiol 17β-tetrahydropyranyl ether
Clinical data
Other names	RS-2290; NSC-99694; Estra-1,3,5(10)-triene-17β-diol 17β-(tetrahydropyran-2-yl) ether; 17β-(Tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-3-ol
Routes of; administration	By mouth
Drug class	Estrogen; Estrogen ether
Identifiers
	IUPAC name (8R,9S,13S,14S,17S)-13-methyl-17-(oxan-2-yloxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol;
CAS Number	3589-90-0;
PubChem CID	23618059;
ChemSpider	19955297;
UNII	OEU4S60XOJ;
Chemical and physical data
Formula	C23H32O3
Molar mass	356.506 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC4CCCCO4)CCC5=C3C=CC(=C5)O;
	InChI InChI=1S/C23H32O3/c1-23-12-11-18-17-8-6-16(24)14-15(17)5-7-19(18)20(23)9-10-21(23)26-22-4-2-3-13-25-22/h6,8,14,18-22,24H,2-5,7,9-13H2,1H3/t18-,19-,20+,21+,22?,23+/m1/s1; Key:DRRJWMXJIVWKKW-CUFSGNDSSA-N;

Estradiol 17β-tetrahydropyranyl ether is a synthetic estrogen and estrogen ether which was never marketed. It has been reported to possess improved oral activity relative to estradiol. One study in animals found that it had 15 times the oral activity of estradiol.