ERBB3

ERBB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS
Identifiers
Aliases	ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK, VSCN1
External IDs	OMIM: 190151; MGI: 95411; HomoloGene: 20457; GeneCards: ERBB3; OMA:ERBB3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,103,505 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,425,521 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; jejunal mucosa; ; spinal ganglia; ; inferior ganglion of vagus nerve; ; corpus callosum; ; mucosa of colon; ; mucosa of ileum; ; mucosa of sigmoid colon; ; duodenum; ; external globus pallidus;
	Top expressed in
	left colon; ; jejunum; ; ileum; ; intestinal villus; ; transitional epithelium of urinary bladder; ; lacrimal gland; ; epidermis; ; hair follicle; ; conjunctival fornix; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activator activity; growth factor binding; protein homodimerization activity; kinase activity; protein binding; identical protein binding; protein heterodimerization activity; ATP binding; transmembrane signaling receptor activity; neuregulin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein tyrosine kinase activity; ubiquitin protein ligase binding; receptor tyrosine kinase; neuregulin receptor activity; transmembrane receptor protein tyrosine kinase activity;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; basolateral plasma membrane; apical plasma membrane; intracellular anatomical structure; receptor complex; extracellular space; cytoplasm; basal plasma membrane;
Biological process	neuron apoptotic process; negative regulation of cell adhesion; phosphorylation; endocardial cushion development; positive regulation of protein tyrosine kinase activity; wound healing; MAPK cascade; positive regulation of calcineurin-NFAT signaling cascade; development of the heart; protein phosphorylation; negative regulation of secretion; regulation of cell population proliferation; extrinsic apoptotic signaling pathway in absence of ligand; phosphatidylinositol 3-kinase signaling; positive regulation of phosphatidylinositol 3-kinase signaling; negative regulation of signal transduction; signal transduction; cranial nerve development; negative regulation of neuron apoptotic process; Schwann cell differentiation; phosphatidylinositol phosphate biosynthetic process; regulation of cell motility; peripheral nervous system development; transmembrane receptor protein tyrosine kinase signaling pathway; ERBB2 signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cardiac muscle tissue development; positive regulation of gene expression; positive regulation of protein kinase B signaling; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; nervous system development; positive regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	2065
	13867
	ENSG00000065361
	ENSMUSG00000018166
	P21860
	Q61526
	NM_001982; NM_001005915
	NM_010153
	NP_001005915; NP_001973
	NP_034283
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.

ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2.