Endothelin converting enzyme 1

ECE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DWB
Identifiers
Aliases	ECE1, ECE, endothelin converting enzyme 1
External IDs	OMIM: 600423; MGI: 1101357; HomoloGene: 1068; GeneCards: ECE1; OMA:ECE1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,345,572 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,692,540 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; left adrenal cortex; ; right adrenal gland; ; popliteal artery; ; tibial arteries; ; right adrenal cortex; ; right lung; ; right coronary artery; ; gastric mucosa; ; canal of the cervix;
	Top expressed in
	aortic valve; ; right lung lobe; ; endothelial cell of lymphatic vessel; ; ascending aorta; ; islet of Langerhans; ; gastrula; ; lip; ; pituitary gland; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; metal ion binding; peptide hormone binding; peptidase activity; protein binding; hydrolase activity; metallopeptidase activity; protein homodimerization activity; metalloendopeptidase activity; zinc ion binding;
Cellular component	Weibel-Palade body; integral component of membrane; vesicle; endosome; membrane; lysosomal membrane; intrinsic component of endosome membrane; perinuclear region of cytoplasm; extracellular exosome; external side of plasma membrane; early endosome; plasma membrane;
Biological process	endothelin maturation; bradykinin catabolic process; regulation of systemic arterial blood pressure by endothelin; embryonic digit morphogenesis; ear development; hormone catabolic process; proteolysis; development of the heart; calcitonin catabolic process; regulation of vasoconstriction; substance P catabolic process; pharyngeal system development; positive regulation of receptor recycling; protein processing; peptide hormone processing;
	Sources:Amigo / QuickGO
Orthologs
	1889
	230857
	ENSG00000117298
	ENSMUSG00000057530
	P42892
	Q4PZA2
	NM_001113347; NM_001113348; NM_001113349; NM_001397
	NM_199307; NM_001369177; NM_001369178; NM_001369179
	NP_001106818; NP_001106819; NP_001106820; NP_001388; NP_001106820.1
	NP_955011; NP_001356106; NP_001356107; NP_001356108
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. It is inhibited by phosphoramidon. ECE1 also mediates melanin production through breaking down inactive Big-EDN1 to produce an active EDN1 in keratinocytes and endothelial cells.