Endothelin 1

EDN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EDN, 1EDP, 1T7H, 1V6R, 6DK5, 5GLH
Identifiers
Aliases	EDN1, ARCND3, ET1, HDLCQ7, QME, endothelin 1, PPET1
External IDs	MGI: 95283; HomoloGene: 1476; GeneCards: EDN1; OMA:EDN1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	12,297,194 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	42,461,466 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; buccal mucosa cell; ; right lung; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; skin of hip; ; human penis; ; islet of Langerhans; ; tibial nerve; ; rectum;
	Top expressed in
	pharynx; ; vasculature of trunk; ; aortic arches; ; right lung lobe; ; dorsal aorta; ; endothelial cell of lymphatic vessel; ; left colon; ; vascular endothelium; ; left lung lobe; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; signaling receptor binding; cytokine activity; endothelin B receptor binding; protein binding; endothelin A receptor binding;
Cellular component	cytoplasm; Weibel-Palade body; basal part of cell; extracellular region; rough endoplasmic reticulum lumen; extracellular space; transport vesicle;
Biological process	skeletal system development; response to amino acid; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of MAP kinase activity; regulation of sensory perception of pain; vasoconstriction; body fluid secretion; positive regulation of sarcomere organization; positive regulation of cardiac muscle hypertrophy; cell surface receptor signaling pathway; multicellular organism aging; artery smooth muscle contraction; cellular response to interferon-gamma; positive regulation of chemokine-mediated signaling pathway; phosphatidylinositol 3-kinase signaling; response to leptin; positive regulation of mitotic nuclear division; cellular response to hypoxia; response to muscle stretch; cellular response to calcium ion; cellular response to transforming growth factor beta stimulus; positive regulation of renal sodium excretion; blood vessel morphogenesis; negative regulation of blood coagulation; response to nicotine; in utero embryonic development; neutrophil chemotaxis; development of the heart; positive regulation of prostaglandin secretion; vein smooth muscle contraction; cartilage development; rhythmic excitation; protein kinase C-activating G protein-coupled receptor signaling pathway; cellular response to glucocorticoid stimulus; branching involved in blood vessel morphogenesis; negative regulation of hormone secretion; positive regulation of smooth muscle contraction; negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin-endoperoxide synthase activity; positive regulation of urine volume; positive regulation of JUN kinase activity; leukocyte activation; membrane depolarization; negative regulation of transcription by RNA polymerase II; response to ozone; respiratory gaseous exchange by respiratory system; positive regulation of heart rate; regulation of blood pressure; response to lipopolysaccharide; response to prostaglandin F; regulation of vasoconstriction; cellular response to interleukin-1; response to salt; positive regulation of cell size; middle ear morphogenesis; sensory perception of pain; prostaglandin biosynthetic process; dorsal/ventral pattern formation; phospholipase D-activating G protein-coupled receptor signaling pathway; positive regulation of odontogenesis; regulation of pH; positive regulation of smooth muscle cell proliferation; protein kinase C deactivation; histamine secretion; maternal process involved in parturition; intracellular signal transduction; response to hypoxia; neural crest cell development; regulation of systemic arterial blood pressure by endothelin; nitric oxide transport; positive regulation of cell migration; response to testosterone; positive regulation of cytosolic calcium ion concentration; epithelial fluid transport; positive regulation of nitric oxide biosynthetic process; cell-cell signaling; cellular response to tumor necrosis factor; response to activity; response to dexamethasone; superoxide anion generation; positive regulation of endothelial cell migration; cellular response to peptide hormone stimulus; cellular response to fatty acid; peptide hormone secretion; cellular response to mineralocorticoid stimulus; positive regulation of cell population proliferation; inositol phosphate-mediated signaling; positive regulation of hormone secretion; negative regulation of smooth muscle cell apoptotic process; calcium-mediated signaling; response to transforming growth factor beta; positive regulation of transcription by RNA polymerase II; positive regulation of DNA-binding transcription factor activity; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of neutrophil chemotaxis; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of glucose transmembrane transport; negative regulation of gene expression; positive regulation of NIK/NF-kappaB signaling; positive regulation of vascular associated smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1906
	13614
	ENSG00000078401
	ENSMUSG00000021367
	P05305
	P22387
	NM_001168319; NM_001955
	NM_010104
	NP_001161791; NP_001946; NP_001161791; NP_001946
	NP_034234
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is the most potent vasoconstrictor produced by the human body. It is a peptide produced by vascular endothelial cells, as well as by cells in the heart (affecting contractility) and kidney (affecting sodium handling). The protein encoded by this gene – EDN1 – is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.