Emopamil binding protein

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3-beta-hydroxysteroid-Δ8,Δ7-isomerase
3-beta-hydroxysteroid-Δ8,Δ7-isomerase
Identifiers
EC no.	5.3.3.5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

EBP
Identifiers
Aliases	EBP, CDPX2, CHO2, CPX, CPXD, MEND, emopamil binding protein (sterol isomerase), cholestenol delta-isomerase, EBP cholestenol delta-isomerase
External IDs	OMIM: 300205; MGI: 107822; HomoloGene: 4798; GeneCards: EBP; OMA:EBP - orthologs
EC number	5.3.3.5
Gene location (Human)
Chr.	X chromosome (human)
End	48,528,716 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	8,059,751 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; mucosa of transverse colon; ; left adrenal cortex; ; tendon of biceps brachii; ; oocyte; ; gingival epithelium; ; buccal mucosa cell;
	Top expressed in
	left lobe of liver; ; esophagus; ; decidua; ; duodenum; ; jejunum; ; right kidney; ; proximal tubule; ; human kidney; ; left colon; ; pyloric antrum;
	More reference expression data
	n/a
Gene ontology
Molecular function	C-8 sterol isomerase activity; isomerase activity; xenobiotic transmembrane transporter activity; transmembrane signaling receptor activity; cholestenol delta-isomerase activity; steroid delta-isomerase activity; protein binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of plasma membrane; endoplasmic reticulum; cytoplasmic vesicle; nuclear envelope; nucleus;
Biological process	skeletal system development; steroid metabolic process; sterol biosynthetic process; lipid metabolism; cholesterol metabolic process; cholesterol biosynthetic process via lathosterol; sterol metabolic process; cholesterol biosynthetic process via desmosterol; steroid biosynthetic process; cholesterol biosynthetic process; xenobiotic transmembrane transport; signal transduction; hemopoiesis; xenobiotic transport;
	Sources:Amigo / QuickGO
Orthologs
	10682
	13595
	ENSG00000147155
	ENSMUSG00000031168
	Q15125
	P70245
	NM_006579
	NM_007898
	NP_006570
	NP_031924
	Wikidata
View/Edit Human	View/Edit Mouse

Emopamil binding protein is a protein that in humans is encoded by the EBP gene, located on the X chromosome. EBP was discovered through its high-affinity binding to anti-ischemic drugs such as emopamil, from which it also derives its name. In addition to emopamil, EBP also bind with high affinity a variety of structurally unrelated compounds, such as amiodarone, opipramol, ifenprodil, trifluoperazine, and chlorpromazine. EBP has a mass of 27.3 kDa and resembles the σ₂-receptor that resides in the endoplasmic reticulum of various tissues as an integral membrane protein.