Effector tumor antigen-specific T cells

Effector tumor antigen–specific T cells (ETASTs) are a specialized group of immune cells that can both recognize and kill cancer cells. They arise from the larger group of tumor antigen–specific T cells (TASTs), which are lymphocytes trained to detect specific antigens expressed by tumors. The amount of polyclonal TASTs (especially effector tumor antigen-specific T cells (ETASTs) can be used as biomarkers for therapeutic efficacy prediction of immunotherapy/chemoimmunotherapy combinations.

In addition, such tumor antigen-specific T cells can be isolated through nanoparticles loading whole tumor antigens and CD137 marker(https://doi.org/10.1016/j.intimp.2025.115695). These isolated and expanded ETAST can be used as therapeutic T cells(https://doi.org/10.1016/j.intimp.2025.115695).

This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.