Ectodysplasin A

EDA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RJ7, 1RJ8
Identifiers
Aliases	EDA, ECTD1, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, XHED, XLHED, TNLG7C, ectodysplasin A
External IDs	OMIM: 300451; MGI: 1195272; GeneCards: EDA; OMA:EDA - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	70,039,472 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	99,444,368 bp
RNA expression pattern
	Top expressed in
	testicle; ; oocyte; ; right auricle of heart; ; left adrenal gland; ; left adrenal cortex; ; secondary oocyte; ; right adrenal cortex; ; gonad; ; apex of heart; ; buccal mucosa cell;
	Top expressed in
	dental lamina; ; saccule; ; ectoderm; ; otic vesicle; ; otic placode; ; outer enamel epithelium; ; entorhinal cortex; ; perirhinal cortex; ; choroid plexus of fourth ventricle; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; tumor necrosis factor receptor binding; signaling receptor binding; death receptor agonist activity; death receptor binding;
Cellular component	integral component of membrane; collagen; endoplasmic reticulum membrane; membrane; plasma membrane; apical part of cell; integral component of plasma membrane; extracellular region; cytoskeleton; lipid droplet; intracellular membrane-bounded organelle;
Biological process	trachea gland development; hair follicle placode formation; hair follicle development; cell differentiation; gene expression; positive regulation of canonical Wnt signaling pathway; salivary gland cavitation; tumor necrosis factor-mediated signaling pathway; multicellular organism development; positive regulation of gene expression; positive regulation of NF-kappaB transcription factor activity; immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; pigmentation; cell-matrix adhesion; skin development; cytokine-mediated signaling pathway; regulation of NIK/NF-kappaB signaling; odontogenesis of dentin-containing tooth; regulation of signaling receptor activity; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	1896
	13607
	ENSG00000158813
	ENSMUSG00000059327
	Q92838
	O54693
NM_001005609; NM_001005610; NM_001005611; NM_001005612; NM_001005613;
	NM_001005614; NM_001399
NM_001177937; NM_001177938; NM_001177939; NM_001177940; NM_001177941;
	NM_001177942; NM_001177943; NM_001177944; NM_010099
	NP_001005609; NP_001005610; NP_001005612; NP_001005613; NP_001390
NP_001171408; NP_001171409; NP_001171410; NP_001171411; NP_001171412;
	NP_001171413; NP_001171414; NP_001171415; NP_034229
	Wikidata
View/Edit Human	View/Edit Mouse

Ectodysplasin A (EDA) is a protein that in humans is encoded by the EDA gene.

Ectodysplasin A is a transmembrane protein of the TNF family which plays an important role in the development of ectodermal tissues such as skin in humans. It is recognized by the ectodysplasin A receptor.