ERM protein family
| Ezrin/radixin/moesin family | |||||||
|---|---|---|---|---|---|---|---|
Crystallographic structure of the N-terminal domain of moesin. | |||||||
| Identifiers | |||||||
| Symbol | ERM | ||||||
| Pfam | PF00769 | ||||||
| InterPro | IPR011259 | ||||||
| SCOP2 | 1ef1 / SCOPe / SUPFAM | ||||||
| |||||||
The ERM protein family consists of three closely related proteins, ezrin, radixin and moesin. The three paralogs, ezrin, radixin and moesin, are present in vertebrates, whereas other species have only one ERM gene. Therefore, in vertebrates these paralogs likely arose by gene duplication.
ERM proteins are highly conserved throughout evolution. More than 75% identity is observed in the N-terminal and the C-terminal of vertebrates (ezrin, radixin, moesin), Drosophila (dmoesin) and C. elegans (ERM-1) homologs.