Epiplakin

EPPK1
Identifiers
Aliases	EPPK1, EPIPL, EPIPL1, epiplakin 1
External IDs	OMIM: 607553; MGI: 2386306; HomoloGene: 20006; GeneCards: EPPK1; OMA:EPPK1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,878,467 bp
RNA expression pattern
	Top expressed in
	skin of hip; ; skin of thigh; ; gingival epithelium; ; epithelium of nasopharynx; ; tail of epididymis; ; germinal epithelium; ; nipple; ; buccal mucosa cell; ; bronchial epithelial cell; ; mucosa of sigmoid colon;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA binding; cytoskeletal protein binding; intermediate filament binding; structural molecule activity; keratin filament binding;
Cellular component	cytoplasm; cytoskeleton; plasma membrane; bicellular tight junction; membrane; basolateral plasma membrane; apicolateral plasma membrane; cell junction; hemidesmosome; cell projection; keratin filament; cell periphery; perinucleolar compartment; intermediate filament;
Biological process	negative regulation of keratinocyte proliferation; negative regulation of cell migration; wound healing; intermediate filament organization; negative regulation of epithelial cell proliferation; negative regulation of keratinocyte migration; negative regulation of wound healing; regulation of epithelium regeneration; cytoskeleton organization; intermediate filament cytoskeleton organization; intermediate filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologs
	83481
	223650
	ENSG00000261150
	ENSMUSG00000115388
	P58107
	Q8R0W0
	NM_031308
	NM_144848
	NP_112598
	NP_659097
	Wikidata
View/Edit Human	View/Edit Mouse

Epiplakin is a large cytoplasmic protein that is encoded by the EPPK1 gene in humans. Epiplakin was first identified as an autoantigen.