EPH receptor A2

EPHA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4PDO, 4TRL, 5EK7
Identifiers
Aliases	EPHA2, Epha2, AW545284, Eck, Myk2, Sek-2, Sek2, ARCC2, CTPA, CTPP1, CTRCT6, EPH receptor A2, ECK
External IDs	OMIM: 176946; MGI: 95278; HomoloGene: 20929; GeneCards: EPHA2; OMA:EPHA2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	16,156,069 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,056,695 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; olfactory zone of nasal mucosa; ; vagina; ; gallbladder; ; skin of abdomen; ; cervix epithelium; ; buccal mucosa cell; ; skin of leg; ; cartilage tissue; ; salivary gland;
	Top expressed in
	neural plate; ; lip; ; tail of embryo; ; lens; ; hair follicle; ; jejunum; ; duodenum; ; endothelial cell of lymphatic vessel; ; epiblast; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase activity; transferase activity; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; cadherin binding; virus receptor activity; transmembrane-ephrin receptor activity;
Cellular component	integral component of membrane; cell projection; membrane; ruffle membrane; cell junction; lamellipodium membrane; leading edge membrane; focal adhesion; integral component of plasma membrane; intracellular anatomical structure; plasma membrane; lamellipodium; cell surface; neuron projection; receptor complex; tight junctions;
Biological process	regulation of lamellipodium assembly; skeletal system development; negative regulation of protein kinase B signaling; cell differentiation; regulation of cell adhesion mediated by integrin; protein kinase B signaling; activation of GTPase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; keratinocyte differentiation; vasculogenesis; multicellular organism development; protein phosphorylation; cell adhesion; blood vessel development; notochord morphogenesis; notochord cell development; angiogenesis; intrinsic apoptotic signaling pathway in response to DNA damage; neural tube development; neuron differentiation; notochord; regulation of ERK1 and ERK2 cascade; cell chemotaxis; post-anal tail morphogenesis; axial mesoderm formation; response to growth factor; viral process; cell migration; apoptotic process; peptidyl-tyrosine phosphorylation; osteoclast differentiation; osteoblast differentiation; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; ephrin receptor signaling pathway; lens fiber cell morphogenesis; mammary gland epithelial cell proliferation; bone remodeling; branching involved in mammary gland duct morphogenesis; negative regulation of cytokine production; defense response to Gram-positive bacterium; negative regulation of lymphangiogenesis; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; pericyte cell differentiation; negative regulation of angiogenesis; inflammatory response; negative regulation of chemokine production; blood vessel morphogenesis; cAMP metabolic process; cell motility; viral entry into host cell; positive regulation of protein localization to plasma membrane; axon guidance; protein localization to plasma membrane; positive regulation of bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	1969
	13836
	ENSG00000142627
	ENSMUSG00000006445
	P29317
	Q03145
	NM_004431; NM_001329090
	NM_010139
	NP_001316019; NP_004422
	NP_034269
	Wikidata
View/Edit Human	View/Edit Mouse

EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene.