Ectonucleotide pyrophosphatase/phosphodiesterase 1

ENPP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YS0
Identifiers
Aliases	ENPP1, ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1, Ectonucleotide pyrophosphatase/phosphodiesterase 1, CD203a
External IDs	OMIM: 173335; MGI: 97370; HomoloGene: 38151; GeneCards: ENPP1; OMA:ENPP1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	131,895,155 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	24,588,057 bp
RNA expression pattern
	Top expressed in
	tibia; ; decidua; ; cartilage tissue; ; tail of epididymis; ; Achilles tendon; ; tendon of biceps brachii; ; liver; ; right lobe of liver; ; synovial joint; ; corpus epididymis;
	Top expressed in
	epithelium of lens; ; fossa; ; condyle; ; transitional epithelium of urinary bladder; ; body of femur; ; right kidney; ; ankle; ; umbilical cord; ; ascending aorta; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleoside-triphosphate diphosphatase activity; calcium ion binding; nucleotide diphosphatase activity; protein homodimerization activity; insulin receptor binding; zinc ion binding; polysaccharide binding; 3'-phosphoadenosine 5'-phosphosulfate binding; metal ion binding; scavenger receptor activity; NADH pyrophosphatase activity; protein binding; catalytic activity; nucleic acid binding; hydrolase activity; ATP binding; phosphodiesterase I activity; exonuclease activity; cyclic-GMP-AMP hydrolase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; lysosomal membrane; basolateral plasma membrane; extracellular space;
Biological process	negative regulation of fat cell differentiation; negative regulation of protein autophosphorylation; regulation of bone mineralization; riboflavin metabolic process; biomineral tissue development; nucleoside triphosphate catabolic process; cellular phosphate ion homeostasis; negative regulation of glycogen biosynthetic process; receptor-mediated endocytosis; generation of precursor metabolites and energy; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; negative regulation of cell growth; immune response; cellular response to insulin stimulus; phosphate-containing compound metabolic process; metabolism; inorganic diphosphate transport; sequestering of triglyceride; ATP metabolic process; nucleic acid phosphodiester bond hydrolysis; vesicle-mediated transport; melanocyte differentiation; negative regulation of bone mineralization; negative regulation of hh target transcription factor activity; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5167
	18605
	ENSG00000197594
	ENSMUSG00000037370
	P22413
	P06802
	NM_006208
	NM_008813; NM_001308327; NM_001308329
	NP_006199
	NP_001295256; NP_001295258; NP_032839
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (PC-1, CD203a) is an enzyme that in humans is encoded by the ENPP1 gene.