EGR2

EGR2
Identifiers
Aliases	EGR2, AT591, CMT1D, CMT4E, KROX20, early growth response 2, CHN1
External IDs	OMIM: 129010; MGI: 95296; HomoloGene: 20123; GeneCards: EGR2; OMA:EGR2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	62,819,167 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	67,542,188 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; tibial nerve; ; granulocyte; ; testicle; ; monocyte; ; gastric mucosa; ; smooth muscle tissue; ; sural nerve; ; skin of abdomen; ; lymph node;
	Top expressed in
	neural ectoderm; ; neuromere; ; rhombomere; ; lip; ; zone of skin; ; spinal nerve; ; ureter; ; urethra; ; thymus; ; male urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; HMG box domain binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; nucleic acid binding; ubiquitin protein ligase binding; transferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; SUMO ligase activity;
Cellular component	cytoplasm; nucleus; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	cellular response to organic substance; rhythmic behavior; peripheral nervous system development; regulation of transcription, DNA-templated; rhombomere 3 development; brain segmentation; transcription by RNA polymerase II; protein sumoylation; rhombomere 3 formation; transcription, DNA-templated; response to insulin; positive regulation of transcription, DNA-templated; brain development; rhombomere 5 formation; protein export from nucleus; learning or memory; skeletal muscle cell differentiation; Schwann cell differentiation; regulation of neuronal synaptic plasticity; myelination; facial nerve structural organization; regulation of ossification; motor neuron axon guidance; fat cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1959
	13654
	ENSG00000122877
	ENSMUSG00000037868
	P11161
	P08152
	NM_000399; NM_001136177; NM_001136178; NM_001136179; NM_001321037
	NM_010118; NM_001347458
	NP_000390; NP_001129649; NP_001129650; NP_001129651; NP_001307966
NP_001334387; NP_034248; NP_001360912; NP_001360914; NP_001360915;
	NP_001360916
	Wikidata
View/Edit Human	View/Edit Mouse

Early growth response protein 2 (EGR2), also known as Krox20, is a transcription factor encoded by the EGR2 gene in humans. It is highly expressed in migrating neural crest cells and later in neural crest-derived cells of the cranial ganglia. Expression of EGR2 is restricted to early hindbrain development, and the gene is evolutionarily conserved among vertebrates, including humans, mice, chicks, and zebrafish. The conservation of its amino acid sequence and embryonic expression pattern underscores its essential role in hindbrain segmentation and neural differentiation.