Disease (Lady Gaga song)

"Disease" is a song by American singer and songwriter Lady Gaga. It was released as the lead single from her studio album Mayhem on October 25, 2024, by Interscope Records. She wrote and produced the track with Andrew Watt and Cirkut, while Michael Polansky provided additional songwriting. "Disease" is an electropop, dark pop, dance-pop, synth-pop, industrial dance, industrial pop, and EDM song with grungy guitars and four-on-the-floor beats. The lyrics explore how love can cure a partner's affliction. "Disease" received acclaim from critics, who praised its production and Gaga's vocal performance. It received a nomination for Best Pop Solo Performance at the 2026 Grammy Awards.

The track peaked at number 14 on the Billboard Global 200 and reached the top 20 in the Czech Republic, Greece, Ireland, Latvia, Slovakia, and the United Kingdom. It was certified double platinum in Brazil and platinum in Canada. The music video for "Disease", directed by Tanu Muino, depicts Gaga facing different versions of herself and trying to control her personified fears. Gaga first performed the track during a Christmas special of Carpool Karaoke in December 2024. She later included it in the set lists of the Mayhem promotional tour (2025) and the Mayhem Ball concert tour (2025–2026).