Dimetacrine

Dimetacrine
Clinical data
Trade names	Istonil, Istonyl, Linostil, Miroistonil
Other names	Dimethacrine, acripramine
Routes of; administration	Oral
ATC code	N06AA18 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); In general: ℞ (Prescription only);
Identifiers
	IUPAC name 3-(9,9-Dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine;
CAS Number	4757-55-5;
PubChem CID	94280;
DrugBank	DB08996 ;
ChemSpider	85085;
UNII	O341NY501N;
KEGG	D02565;
CompTox Dashboard (EPA)	DTXSID4022941 ;
Chemical and physical data
Formula	C20H26N2
Molar mass	294.442 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C;

Dimetacrine (also known as dimethacrine and acripramine; brand names Istonil, Istonyl, Linostil, and Miroistonil) is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.

Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).