Dihydropyrimidine dehydrogenase (NADP+)
| dihydropyrimidine dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Dihydroprymidine dehydrogenase dimer, Sus scrofa | |||||||||
| Identifiers | |||||||||
| EC no. | 1.3.1.2 | ||||||||
| CAS no. | 9029-01-0 | ||||||||
| Alt. names | Dihydrothymine dehydrogenase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, dihydropyrimidine dehydrogenase (NADP+) (EC 1.3.1.2) is an enzyme that catalyzes the chemical reaction
In the catabolism of uracil, the enzyme converts uracil to dihydrouracil using nicotinamide adenine dinucleotide phosphate (NADPH) as its cofactor. It can also act on thymine to give dihydrothymine.
In humans the enzyme is encoded by the DPYD gene. It is the initial and rate-limiting step in pyrimidine catabolism. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur. It participates in beta-alanine metabolism and pantothenate and coa biosynthesis.