Dibutyl squarate

Dibutyl squarate
Names
	IUPAC name 3,4-Dibutoxy-3-cyclobutene-1,2-dione
	Other names Squaric acid dibutyl ester; SADBE
Identifiers
CAS Number	2892-62-8 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	1968189
ChEBI	CHEBI:53612;
ChEMBL	ChEMBL2435707;
ChemSpider	58618;
DrugBank	DB12223;
ECHA InfoCard	100.157.137
EC Number	628-906-7;
PubChem CID	65108;
UNII	4RTO57VG65;
CompTox Dashboard (EPA)	DTXSID30183113 ;
	InChI InChI=1S/C12H18O4/c1-3-5-7-15-11-9(13)10(14)12(11)16-8-6-4-2/h3-8H2,1-2H3 Key: XBRWELTXMQSEIN-UHFFFAOYSA-N;
	SMILES CCCCOC1=C(C(=O)C1=O)OCCCC;
Properties
Chemical formula	C12H18O4
Molar mass	226.272 g·mol−1
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H317, H319, H335
Precautionary statements	P261, P264, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P313, P337+P317, P362+P364, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Dibutyl squarate (also known as squaric acid dibutyl ester or SADBE) is a chemical compound with the molecular formula C₁₂H₁₈O₄. It is the dibutyl derivative of squaric acid.

Medically, it is used for the treatment of warts and for treating alopecia areata or alopecia totalis (autoimmune hair loss) through topical immunotherapy involving the production of an allergic rash. Dibutyl squarate is currently undergoing trials for use in treating herpes labialis (cold sores).