Death receptor 5

TNFRSF10B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D0G, 1D4V, 1DU3, 1ZA3, 2H9G, 4I9X, 4N90, 4OD2, 3X3F
Identifiers
Aliases	TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, tumor necrosis factor receptor superfamily member 10b, TNF receptor superfamily member 10b
External IDs	OMIM: 603612; MGI: 1341090; HomoloGene: 117702; GeneCards: TNFRSF10B; OMA:TNFRSF10B - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,069,031 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,021,860 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; mucosa of urinary bladder; ; blood; ; vena cava; ; stromal cell of endometrium; ; gallbladder; ; germinal epithelium; ; pericardium; ; visceral pleura; ; tibia;
	Top expressed in
	urethra; ; female urethra; ; male urethra; ; genital tubercle; ; morula; ; endothelial cell of lymphatic vessel; ; tail of embryo; ; lens; ; embryo; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	TRAIL binding; protein binding; tumor necrosis factor-activated receptor activity; signaling receptor activity;
Cellular component	membrane; plasma membrane; integral component of plasma membrane; cell surface; intracellular anatomical structure; integral component of membrane;
Biological process	activation of NF-kappaB-inducing kinase activity; response to endoplasmic reticulum stress; multicellular organism development; cell surface receptor signaling pathway; response to lipopolysaccharide; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; cellular response to mechanical stimulus; regulation of cell population proliferation; immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway via death domain receptors; inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; signal transduction; tumor necrosis factor-mediated signaling pathway; apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; leukocyte migration; extrinsic apoptotic signaling pathway via death domain receptors; regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TRAIL-activated apoptotic signaling pathway; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8795
	21933
	ENSG00000120889
	ENSMUSG00000022074
	O14763
	Q9QZM4
	NM_003842; NM_147187
	NM_020275
	NP_003833; NP_671716
	NP_064671
	Wikidata
View/Edit Human	View/Edit Mouse

Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.