DESeq2

DESeq2
Original authorsMichael Love
Constantin Ahlmann-Eltze
Kwame Forbes
Simon Anders
Wolfgang Huber
Initial release22 March 2013 (2013-03-22)
Stable release
1.51.6 / 1 December 2025 (2025-12-01)
Operating systemLinux, macOS, Windows
PlatformR programming language
TypeBioinformatics
LicenseGNU Lesser General Public License
WebsiteDESeq2 on Bioconductor
RepositoryDESeq2 on GitHub

DESeq2 is a software package in the field of bioinformatics and computational biology for the statistical programming language R. It is primarily employed for the analysis of high-throughput RNA sequencing (RNA-seq) data to identify differentially expressed genes between different experimental conditions. DESeq2 employs statistical methods to normalize and analyze RNA-seq data, making it a valuable tool for researchers studying gene expression patterns and regulation. It is available through the Bioconductor repository.

It was first presented in 2014. As of February 2026, its use has been cited over 86,000 times.