DDX3X

DDX3X
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I4I, 2JGN, 3JRV, 4O2C, 4O2E, 4O2F, 4PX9, 4PXA, 5E7J, 5E7M, 5E7I
Identifiers
Aliases	DDX3X, DBX, DDX14, DDX3, HLP2, CAP-Rf, MRX102, DEAD-box helicase 3, X-linked, DEAD-box helicase 3 X-linked, MRXSSB
External IDs	OMIM: 300160; MGI: 103064; HomoloGene: 3425; GeneCards: DDX3X; OMA:DDX3X - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	41,364,472 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	13,160,291 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; oocyte; ; sperm; ; secondary oocyte; ; palpebral conjunctiva; ; lactiferous duct; ; tibia; ; mucosa of paranasal sinus; ; skin of hip; ; epithelium of colon;
	Top expressed in
	maxillary prominence; ; cumulus cell; ; human fetus; ; tail of embryo; ; mandibular prominence; ; primitive streak; ; lacrimal gland; ; genital tubercle; ; epithelium of stomach; ; ureter;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; nucleoside-triphosphatase activity; CTPase activity; helicase activity; poly(A) binding; ribosomal small subunit binding; RNA stem-loop binding; DNA helicase activity; transcription factor binding; ATPase activity; protein binding; GTPase activity; eukaryotic initiation factor 4E binding; RNA binding; nucleic acid binding; mRNA 5'-UTR binding; translation initiation factor binding; hydrolase activity; ATP binding; RNA strand annealing activity; cadherin binding; protein serine/threonine kinase activator activity;
Cellular component	cytoplasm; eukaryotic translation initiation factor 3 complex; nuclear speck; membrane; mitochondrial outer membrane; cytosolic small ribosomal subunit; mitochondrion; cytoplasmic stress granule; extracellular exosome; nucleus; extracellular region; cytosol; secretory granule lumen; ficolin-1-rich granule lumen; nucleolus;
Biological process	stress granule assembly; apoptotic process; negative regulation of translation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; intracellular signal transduction; regulation of transcription, DNA-templated; ribosome biogenesis; negative regulation of intrinsic apoptotic signaling pathway; immune system process; chromosome segregation; negative regulation of protein-containing complex assembly; response to virus; negative regulation of apoptotic process; Wnt signaling pathway; positive regulation of translation; protein localization to cytoplasmic stress granule; transcription, DNA-templated; cellular response to osmotic stress; positive regulation of G1/S transition of mitotic cell cycle; intrinsic apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cell growth; positive regulation of gene expression; mature ribosome assembly; cellular response to arsenic-containing substance; negative regulation of cell growth; positive regulation of chemokine (C-C motif) ligand 5 production; RNA secondary structure unwinding; positive regulation of apoptotic process; positive regulation of viral genome replication; viral process; innate immune response; positive regulation of translational initiation; regulation of translation; extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of transcription by RNA polymerase II; positive regulation of interferon-beta production; DNA duplex unwinding; neutrophil degranulation; positive regulation of protein serine/threonine kinase activity; positive regulation of canonical Wnt signaling pathway; translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	1654
	13205
	ENSG00000215301
	ENSMUSG00000000787
	O00571
	Q62167
	NM_001193416; NM_001193417; NM_001356; NM_024005; NM_001363819
	NM_010028; NM_008015
	NP_001180345; NP_001180346; NP_001347; NP_001350748
	NP_034158
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent RNA helicase DDX3X is an enzyme that in humans is encoded by the DDX3X gene.