Cyclin-dependent kinase
| Cyclin-dependent kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.11.22 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases involved in the regulation of the cell cycle. These enzymes function as upstream regulators of cellular processes such as transcription, DNA repair, metabolism, and epigenetic regulation, in response to extracellular and intracellular signals. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.
CDKs are named for the cyclins, protein activators of CDKs that become mobilized at different points in the cell cycle. Dysregulation of CDK activity is linked to diseases including cancer, neurodegenerative diseases, and stroke.