Cychlorphine

Not to be confused with Cyclorphan.

Cychlorphine
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
Identifiers
CAS Number
PubChem CID
ChemSpider
ECHA InfoCard100.006.468
Chemical and physical data
FormulaC23H25ClN4O
Molar mass408.93 g·mol−1
3D model (JSmol)
  • CC(C1=CC=C(C=C1)Cl)N2CCC(CC2)N3C4=CC=CC=C4N(C3=O)CCC#N
  • InChI=1S/C23H25ClN4O/c1-17(18-7-9-19(24)10-8-18)26-15-11-20(12-16-26)28-22-6-3-2-5-21(22)27(23(28)29)14-4-13-25/h2-3,5-10,17,20H,4,11-12,14-16H2,1H3
  • Key:SWWAVNFEFVMDAG-UHFFFAOYSA-N

Cychlorphine (N-Propionitrile chlorphine) is a synthetic opioid chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the USA. It has been found in Canada as of September 2025. It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine has been published. It is not a structural analog of morphine, despite the similar name. Instead, it is an orphine.

At least 5 people have died from a cychlorphine overdose in England in 2025. Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses.

It was added to the German NpSG in December 2025.

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