Creatine
Skeletal formula of neutral form of creatine
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Skeletal formula of one of the zwitterionic forms of creatine
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Ball and stick model of one zwitterionic form of creatine
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| Names | |
|---|---|
| Systematic IUPAC name
2-[Carbamimidoyl(methyl)amino]acetic acid | |
| Other names
N-Carbamimidoyl-N-methylglycine; Methylguanidoacetic acid; N-amidinosarcosine
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| Identifiers | |
3D model (JSmol)
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| 907175 | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.000.278 |
| EC Number |
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| 240513 | |
| KEGG | |
| MeSH | Creatine |
PubChem CID
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| RTECS number |
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C4H9N3O2 | |
| Molar mass | 131.135 g·mol−1 |
| Appearance | White crystals |
| Odor | Odourless |
| Density | 1.33 g/cm3 |
| Melting point | 255 °C (491 °F; 528 K) |
| 13.3 g L−1 (at 18 °C) | |
| log P | −1.258 |
| Vapor pressure | 0.001 mmHg |
| Acidity (pKa) | 3.429 |
| Basicity (pKb) | 10.568 |
| Isoelectric point | 8.47 |
| Thermochemistry | |
Heat capacity (C)
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171.1 J K−1 mol−1 (at 23.2 °C) |
Std molar
entropy (S⦵298) |
189.5 J K−1 mol−1 |
Std enthalpy of
formation (ΔfH⦵298) |
−538.06–−536.30 kJ mol−1 |
Std enthalpy of
combustion (ΔcH⦵298) |
−2.3239–−2.3223 MJ mol−1 |
| Pharmacology | |
| C01EB06 (WHO) | |
| Pharmacokinetics: | |
| 3 hours | |
| Hazards | |
| GHS labelling: | |
| Warning | |
| H315, H319, H335 | |
| P261, P305+P351+P338 | |
| NFPA 704 (fire diamond) | |
| Flash point | 118.1 °C (244.6 °F; 391.2 K) |
| > 400 °C | |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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> 2000 mg/kg (dermal, rat) |
| Safety data sheet (SDS) | ChemicalBook |
| Related compounds | |
Related alkanoic acids
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Related compounds
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Dimethylacetamide |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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Creatine (/ˈkriːətiːn/ or /ˈkriːətɪn/) is an organic compound that, in vertebrates, facilitates recycling of adenosine triphosphate (ATP), primarily in muscle and brain tissue. Its phosphorylated form, phosphocreatine, donates phosphate groups to adenosine diphosphate (ADP), turning it back into ATP. Creatine also acts as a buffer. It has the nominal formula (H2N)(HN)CN(CH3)CH2CO2H and in solutions, exists in various tautomers, including a neutral form and zwitterionic forms.