Conserved oligomeric Golgi complex

The conserved oligomeric Golgi complex, also known as the COG complex, is an extrinsic membrane protein found on the Golgi apparatus within eukaryotes . This complex is evolutionarily conserved and has homologous subunits found within every species of eukaryote. The COG complex was first discovered in 1981 in Chinese hamster ovary cells . These ovary cells had mutations in low-density lipoprotein (LDL) receptors, which affected the function of Golgi glycosylation enzymes . However, the COG complex as a whole was not fully understood until 2004 when a deficiency in one of the COG subunits was linked to congenital disorders of glycosylation . These findings led to the realization that the COG complex plays an important role in glycosylation and protein sorting .

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