Cognitive reserve

Cognitive reserve is a property of the brain that allows for cognitive performance that is better than expected given the degree of life-course–related brain changes and brain injury or disease. In this context, cognitive reserve can be understood as a key contributor to cognitive resilience, reflecting the brain’s capacity to withstand or adapt to neuropathological burden. The conceptualization of cognitive reserve as a property of the brain encompasses multiple potential mechanisms operating at molecular, cellular, and network levels. The working hypothesis is that these mechanisms enable coping with or compensation for brain changes and the consequences of brain injury or disease.

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