Carbohydrate-responsive element-binding protein

MLXIPL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GNT
Identifiers
Aliases	MLXIPL, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14, MLX interacting protein like, MLX
External IDs	OMIM: 605678; MGI: 1927999; HomoloGene: 32507; GeneCards: MLXIPL; OMA:MLXIPL - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,624,543 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,167,236 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; right hemisphere of cerebellum; ; subcutaneous adipose tissue; ; gastric mucosa; ; gastrocnemius muscle; ; right testis; ; muscle of thigh;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; left lobe of liver; ; brown adipose tissue; ; islet of Langerhans; ; muscle of thigh; ; proximal tubule; ; zygote; ; soleus muscle; ; right kidney; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate response element binding; DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	intracellular signal transduction; positive regulation of lipid biosynthetic process; regulation of transcription, DNA-templated; glucose homeostasis; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; negative regulation of transcription by RNA polymerase II; positive regulation of fatty acid biosynthetic process; transcription, DNA-templated; positive regulation of transcription, DNA-templated; fatty acid homeostasis; positive regulation of cell population proliferation; negative regulation of peptidyl-serine phosphorylation; glucose mediated signaling pathway; negative regulation of oxidative phosphorylation; negative regulation of transcription, DNA-templated; positive regulation of glycolytic process; triglyceride homeostasis; positive regulation of transcription by RNA polymerase II; cellular response to carbohydrate stimulus; energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	51085
	58805
	ENSG00000009950
	ENSMUSG00000005373
	Q9NP71
	Q99MZ3
	NM_032951; NM_032952; NM_032953; NM_032954; NM_032994
	NM_021455; NM_001359237
	NP_116569; NP_116570; NP_116571; NP_116572
	NP_067430; NP_001346166
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate-responsive element-binding protein (ChREBP), also known as MLX-interacting protein-like (MLXIPL), MondoB, and WBSCR14, is a protein that in humans is encoded by the Mlxipl gene. ChREBP has two isoforms, ChREBP-α and ChREBP-β, which are encoded by the same gene using alternative promoters.

ChREBP is a member of the Mondo family and Myc / Max / Mad superfamily of transcription factors. The two main members of the Mondo family are MondoA (MLX-interacting protein or MLXIP) and ChREBP (MondoB, MLXIPL). Both are characterized by a basic helix-loop-helix leucine zipper (bHLH-ZIP) structure, and form heterodimers with MLX protein.

ChREBP is a sugar-sensing transcription factor, mediating genomic responses to carbohydrate availability in metabolic tissues such as liver and adipose tissue. ChREBP is crucial in nutrient sensing, glucose uptake and regulation of nutrient metabolism and energy homeostasis through metabolic processes such as glycolysis and lipogenesis. However, many of the mechanisms involved are not yet well understood.