Caveolin 3

CAV3
Identifiers
Aliases	CAV3, LGMD1C, LQT9, VIP-21, VIP21, caveolin 3, MPDT, RMD2
External IDs	OMIM: 601253; MGI: 107570; HomoloGene: 7255; GeneCards: CAV3; OMA:CAV3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	8,841,808 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	112,449,833 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; vastus lateralis muscle; ; triceps brachii muscle; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; gastrocnemius muscle; ; deltoid muscle; ; tibialis anterior muscle;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; interventricular septum; ; plantaris muscle; ; soleus muscle; ; extensor digitorum longus muscle; ; temporal muscle; ; masseter muscle; ; thoracic diaphragm; ; extraocular muscle; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; protein C-terminus binding; potassium channel inhibitor activity; calcium channel regulator activity; protein binding; molecular adaptor activity; sodium channel regulator activity; connexin binding; alpha-tubulin binding; protein-containing complex binding; enzyme binding; nitric-oxide synthase binding; structural molecule activity;
Cellular component	cytoplasm; membrane; T-tubule; dystrophin-associated glycoprotein complex; cell surface; Z discdkac; endoplasmic reticulum; membrane raft; Golgi apparatus; intracellular membrane-bounded organelle; intercalated disc; neuromuscular junction; plasma membrane; vesicle; Golgi membrane; sarcolemma; caveola; protein-containing complex; integral component of plasma membrane; focal adhesion;
Biological process	myotube differentiation; muscle contraction; regulation of heart contraction; muscle cell cellular homeostasis; negative regulation of cardiac muscle hypertrophy; negative regulation of membrane depolarization during cardiac muscle cell action potential; regulation of membrane potential; muscle organ development; regulation of calcium ion import; plasma membrane repair; regulation of signaling; membrane raft organization; regulation of sodium ion transmembrane transporter activity; positive regulation of microtubule polymerization; cholesterol homeostasis; triglyceride metabolic process; negative regulation of cell size; regulation of skeletal muscle contraction; T-tubule organization; regulation of ventricular cardiac muscle cell membrane depolarization; heart trabecula formation; glucose homeostasis; actin filament organization; cardiac muscle cell development; regulation of branching involved in mammary gland duct morphogenesis; ventricular cardiac muscle cell action potential; detection of muscle stretch; regulation of signal transduction by receptor internalization; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of MAP kinase activity; cytoplasmic microtubule organization; regulation of nerve growth factor receptor activity; regulation of protein kinase B signaling; negative regulation of potassium ion transmembrane transport; regulation of p38MAPK cascade; protein localization to plasma membrane; plasma membrane organization; regulation of membrane depolarization during cardiac muscle cell action potential; negative regulation of sarcomere organization; cell differentiation; negative regulation of protein kinase activity; nucleus localization; regulation of heart rate; negative regulation of protein localization to cell surface; positive regulation of ubiquitin-dependent protein catabolic process; negative regulation of MAPK cascade; myoblast fusion; regulation of calcium ion transmembrane transporter activity; protein localization; positive regulation of myotube differentiation; positive regulation of caveolin-mediated endocytosis; regulation of calcium ion transport; endocytosis; negative regulation of nitric-oxide synthase activity; caveola assembly; positive regulation of cytosolic calcium ion concentration; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of potassium ion transmembrane transporter activity; positive regulation of cell population proliferation; negative regulation of calcium ion transport; regulation of cardiac muscle contraction; regulation of ventricular cardiac muscle cell membrane repolarization; regulation of cardiac muscle cell action potential involved in regulation of contraction; cellular response to organonitrogen compound;
	Sources:Amigo / QuickGO
Orthologs
	859
	12391
	ENSG00000182533
	ENSMUSG00000062694
	P56539
	P51637
	NM_033337; NM_001234
	NM_007617
	NP_001225; NP_203123
	NP_031643
	Wikidata
View/Edit Human	View/Edit Mouse

Caveolin-3 is a protein that in humans is encoded by the CAV3 gene. Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.