Cathepsin C

Available protein structures:
PDB	IPR014882 PF08773 (ECOD; PDBsum)
AlphaFold	IPR014882; PF08773;

Cathepsin C exclusion domain
Cathepsin C exclusion domain
	re-determination of the native structure of human dipeptidyl peptidase i (cathepsin c)
Identifiers
Symbol	CathepsinC_exc
Pfam	PF08773
InterPro	IPR014882
SCOP2	1k3b / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	IPR014882 PF08773 (ECOD; PDBsum)
AlphaFold	IPR014882; PF08773;

CTSC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OEM, 1K3B, 2DJF, 2DJG, 3PDF, 4CDC, 4CDD, 4CDE, 4CDF, 4OEL
Identifiers
Aliases	CTSC, CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS, cathepsin C
External IDs	OMIM: 602365; MGI: 109553; HomoloGene: 1373; GeneCards: CTSC; OMA:CTSC - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	88,359,684 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	87,960,096 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; epithelium of nasopharynx; ; stromal cell of endometrium; ; gallbladder; ; appendix; ; bronchial epithelial cell; ; lymph node; ; rectum; ; monocyte; ; granulocyte;
	Top expressed in
	left lung lobe; ; right lung lobe; ; hair follicle; ; stroma of bone marrow; ; carotid body; ; yolk sac; ; parotid gland; ; primitive streak; ; ciliary body; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activator activity involved in apoptotic process; phosphatase binding; cysteine-type peptidase activity; chaperone binding; protein self-association; peptidase activity; protein binding; identical protein binding; chloride ion binding; cysteine-type endopeptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	Golgi apparatus; endoplasmic reticulum lumen; membrane; endoplasmic reticulum; COPII-coated ER to Golgi transport vesicle; lysosome; extracellular exosome; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi membrane; extracellular region; extracellular space; nucleoplasm; centrosome; azurophil granule lumen; intracellular membrane-bounded organelle; collagen-containing extracellular matrix; cytoplasm;
Biological process	ageing; positive regulation of proteolysis involved in cellular protein catabolic process; positive regulation of apoptotic signaling pathway; response to organic substance; proteolysis; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; immune response; proteolysis involved in cellular protein catabolic process; T cell mediated cytotoxicity; apoptotic process; neutrophil degranulation; negative regulation of myelination; positive regulation of microglial cell activation;
	Sources:Amigo / QuickGO
Orthologs
	1075
	13032
	ENSG00000109861
	ENSMUSG00000030560
	P53634
	P97821
	NM_148170; NM_001114173; NM_001814
	NM_009982; NM_001311790
	NP_001107645; NP_001805; NP_680475
	NP_001298719; NP_034112
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I or DPP1) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. In humans, it is encoded by the CTSC gene.