Caspase 8

CASP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7, 4PRZ, 4PS1, 4ZBW
Identifiers
Aliases	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, caspase 8
External IDs	OMIM: 601763; MGI: 1261423; HomoloGene: 7657; GeneCards: CASP8; OMA:CASP8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,287,711 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,886,662 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; buccal mucosa cell; ; bone marrow cell; ; spleen; ; lymph node; ; appendix; ; epithelium of colon; ; rectum;
	Top expressed in
	jejunum; ; duodenum; ; ileum; ; subcutaneous adipose tissue; ; parotid gland; ; lymph node; ; stroma of bone marrow; ; spleen; ; endothelial cell of lymphatic vessel; ; embryonic cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	death effector domain binding; cysteine-type peptidase activity; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; scaffold protein binding; protein binding; identical protein binding; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity; hydrolase activity; ubiquitin protein ligase binding; peptidase activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; death receptor binding; tumor necrosis factor receptor binding; protein-containing complex binding;
Cellular component	cell body; cytosol; CD95 death-inducing signaling complex; ripoptosome; nucleoplasm; mitochondrial outer membrane; death-inducing signaling complex; membrane raft; neuron projection; cytoskeleton; cytoplasm; mitochondrion; nucleus; protein-containing complex;
Biological process	regulation of apoptotic process; response to estradiol; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; response to antibiotic; regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of macrophage differentiation; cellular response to organic cyclic compound; natural killer cell activation; negative regulation of I-kappaB kinase/NF-kappaB signaling; TRAIL-activated apoptotic signaling pathway; proteolysis; macrophage differentiation; TRIF-dependent toll-like receptor signaling pathway; response to tumor necrosis factor; B cell activation; cell surface receptor signaling pathway; response to lipopolysaccharide; cellular response to mechanical stimulus; activation of cysteine-type endopeptidase activity; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; death-inducing signaling complex assembly; positive regulation of proteolysis; positive regulation of I-kappaB kinase/NF-kappaB signaling; apoptotic signaling pathway; response to cold; regulation of extrinsic apoptotic signaling pathway via death domain receptors; viral process; response to ethanol; response to cobalt ion; activation of cysteine-type endopeptidase activity involved in apoptotic process; proteolysis involved in cellular protein catabolic process; syncytiotrophoblast cell differentiation involved in labyrinthine layer development; nucleotide-binding oligomerization domain containing signaling pathway; T cell activation; suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of necroptotic process; execution phase of apoptosis; toll-like receptor 3 signaling pathway; positive regulation of neuron death; extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of interleukin-1 beta production;
	Sources:Amigo / QuickGO
Orthologs
	841
	12370
	ENSG00000064012
	ENSMUSG00000026029
	Q14790
	O89110
NM_001080124; NM_001080125; NM_001228; NM_033355; NM_033356;
	NM_033357; NM_033358; NM_001372051
	NM_001080126; NM_001277926; NM_009812
NP_001073593; NP_001073594; NP_001219; NP_203519; NP_203520;
	NP_203522; NP_001358980
	NP_001073595; NP_001264855; NP_033942
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.