Caspase 4

CASP4
Identifiers
Aliases	CASP4, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX, Mih1, caspase 4
External IDs	OMIM: 602664; MGI: 107700; HomoloGene: 136493; GeneCards: CASP4; OMA:CASP4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	104,969,366 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	5,336,783 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; Achilles tendon; ; upper lobe of left lung; ; body of pancreas; ; gallbladder; ; right lung; ; spleen; ; epithelium of colon;
	Top expressed in
	granulocyte; ; jejunum; ; ileum; ; duodenum; ; large intestine; ; Paneth cell; ; colon; ; endothelial cell of lymphatic vessel; ; uterus; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; peptidase activity; hydrolase activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity; CARD domain binding; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; protein binding;
Cellular component	NLRP3 inflammasome complex; cytoplasm; endoplasmic reticulum membrane; membrane; extracellular region; AIM2 inflammasome complex; IPAF inflammasome complex; endoplasmic reticulum; mitochondrion; inflammasome complex; cytosol; plasma membrane; protein-containing complex;
Biological process	regulation of apoptotic process; programmed cell death; immune system process; proteolysis; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of inflammatory response; innate immune response; inflammatory response; cellular response to amyloid-beta; apoptotic process; execution phase of apoptosis; positive regulation of tumor necrosis factor-mediated signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	837
	12363
	ENSG00000196954
	ENSMUSG00000033538
	P49662
	P70343
	NM_001225; NM_033306; NM_033307
	NM_007609
	NP_001216; NP_150649
NP_031635; NP_001366247; NP_001366248; NP_001366249; NP_001366250;
	NP_001366251; NP_001366252
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase 4 is an enzyme that in human is encoded by the CASP4 gene.

Caspase 4 proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.