Cardiotrophin 1

CTF1
Identifiers
Aliases	CTF1, cardiotrophin 1, CT-1, CT1
External IDs	OMIM: 600435; MGI: 105115; HomoloGene: 1016; GeneCards: CTF1; OMA:CTF1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,903,547 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,317,364 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; body of uterus; ; popliteal artery; ; tibial arteries; ; left ovary; ; right auricle of heart; ; right ovary; ; left ventricle; ; canal of the cervix;
	Top expressed in
	vestibular membrane of cochlear duct; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; epithelium of lens; ; ciliary body; ; vestibular sensory epithelium; ; muscle of thigh; ; choroid plexus of fourth ventricle; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; leukemia inhibitory factor receptor binding;
Cellular component	extracellular space; extracellular region;
Biological process	cell-cell signaling; cell surface receptor signaling pathway; muscle organ development; leukemia inhibitory factor signaling pathway; cell population proliferation; neuron development; nervous system development; positive regulation of cell population proliferation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1489
	13019
	ENSG00000150281
	ENSMUSG00000042340
	Q16619
	Q60753
	NM_001142544; NM_001330
	NM_001301282; NM_001301283; NM_007795
	NP_001136016; NP_001321
	NP_001288211; NP_001288212; NP_031821
	Wikidata
View/Edit Human	View/Edit Mouse

Cardiotrophin-1 (CT-1) is a protein encoded by the CTF1 gene in humans. It functions as a cytokine and acts as a 21.5 kDa cardiac hypertrophic factor. CT-1 belongs to the IL-6 cytokine family.