Carbidopa/levodopa

Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. It is primarily used to manage the symptoms of Parkinson's disease, although it does not slow down the disease or slow down progression. It can take two to three weeks of treatment before benefits are seen. Each dose then begins working in about ten minutes to two hours, with a duration of effect of about five hours. Carbidopa/levodopa is taken orally

Common side effects include movement problems and nausea. More serious side effects include depression, low blood pressure with standing, sudden onset of sleepiness, psychosis, and increased risk-taking behavior. Carbidopa prevents the breakdown of levodopa outside the brain. In the brain, levodopa is broken down into dopamine – its active form. Carbidopa also helps prevent some of the nausea which levodopa causes.

It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2023, it was the 310th most commonly prescribed medication in the United States, with more than 200,000 prescriptions.