Callystatin A

Callystatin A
Names
	Preferred IUPAC name (6R)-6-[(1E,3Z,5R,7E,9E,11R,13S,14R,15S)-3-Ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxoheptadeca-1,3,7,9-tetraen-1-yl]-5,6-dihydro-2H-pyran-2-one
	Other names (−)-Callystatin A
Identifiers
CAS Number	189883-16-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:435273 ;
ChEMBL	ChEMBL200899 ;
ChemSpider	4581330 ;
KEGG	C16891 ;
MeSH	A (-)-Callystatin A
PubChem CID	5471086;
UNII	ZLK7N2R2D6 ;
CompTox Dashboard (EPA)	DTXSID501029737 ;
	InChI InChI=1S/C29H44O4/c1-8-22(5)28(31)24(7)29(32)23(6)18-20(3)12-10-13-21(4)19-25(9-2)16-17-26-14-11-15-27(30)33-26/h10-12,15-19,21-24,26,28,31H,8-9,13-14H2,1-7H3/b12-10+,17-16+,20-18+,25-19-/t21-,22+,23-,24+,26-,28-/m1/s1 Key: QPJTWGLLJWBDQW-KMMMXHTBSA-N ;
	SMILES CC[C@H](C)[C@H]([C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)/C=C(/CC)\C=C\[C@H]1CC=CC(=O)O1)O;
Properties
Chemical formula	C29H44O4
Molar mass	456.6573 g/mol
Density	1.022 g/cm3
Boiling point	622 °C (1,152 °F; 895 K) at 760 mmHg
Hazards
Flash point	196 °C (385 °F; 469 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Callystatin A is a polyketide natural product from the leptomycin family of secondary metabolites. It was first isolated in 1997 from the marine sponge Callyspongia truncata which was collected from the Goto Islands in the Nagasaki Prefecture of Japan by the Kobayashi group. Since then its absolute configuration has been elucidated and callystatin A was discovered to have anti-fungal and anti-tumor activities with extreme potency against the human epidermoid carcinoma KB cells (IG₅₀ = 10 pg/ml) and the mouse lymphocytic leukemia Ll210 cells (IG₅₀ = 20 pg/ml).