CYP8B1

CYP8B1
Identifiers
Aliases	CYP8B1, CP8B, CYP12, cytochrome P450 family 8 subfamily B member 1
External IDs	OMIM: 602172; MGI: 1338044; HomoloGene: 3233; GeneCards: CYP8B1; OMA:CYP8B1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	42,875,898 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	121,745,371 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; tibialis anterior muscle; ; sural nerve; ; pancreatic ductal cell; ; renal cortex; ; renal medulla; ; gallbladder; ; right coronary artery; ; left coronary artery; ; human kidney;
	Top expressed in
	left lobe of liver; ; gallbladder; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; esophagus; ; lip; ; muscle of thigh; ; central gray substance of midbrain; ; nucleus of stria terminalis; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	monooxygenase activity; iron ion binding; oxygen binding; oxidoreductase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity; sterol 12-alpha-hydroxylase activity;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	sterol metabolic process; bile acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1582
	13124
	ENSG00000180432
	ENSMUSG00000050445
	Q9UNU6
	O88962
	NM_004391
	NM_010012
	NP_004382
	NP_034142
	Wikidata
View/Edit Human	View/Edit Mouse

CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.