Cubilin

CUBN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KQ4
Identifiers
Aliases	CUBN, IFCR, MGA1, gp280, cubilin, IGS, IGS1
External IDs	OMIM: 602997; MGI: 1931256; HomoloGene: 37434; GeneCards: CUBN; OMA:CUBN - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,129,811 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,496,624 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; glomerulus; ; renal medulla; ; metanephric glomerulus; ; sperm; ; oocyte; ; right uterine tube; ; human kidney; ; gonad; ; secondary oocyte;
	Top expressed in
	primitive streak; ; yolk sac; ; ileum; ; human kidney; ; epithelium of small intestine; ; intestinal villus; ; jejunum; ; epithelium of lens; ; Ileal epithelium; ; right kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; protein binding; transporter activity; cobalamin binding; metal ion binding; channel regulator activity; hemoglobin binding; signaling receptor activity; cargo receptor activity;
Cellular component	brush border; extrinsic component of external side of plasma membrane; endoplasmic reticulum; clathrin-coated pit; lysosomal membrane; cytoplasm; Golgi apparatus; endosome; apical part of cell; lysosome; lysosomal lumen; membrane; cytosol; extracellular exosome; endocytic vesicle; endosome membrane; plasma membrane; apical plasma membrane; brush border membrane; Golgi-associated vesicle; ionotropic glutamate receptor complex; coated vesicle; endocytic vesicle membrane; neuron projection membrane; synapse;
Biological process	tissue homeostasis; cobalamin transport; lipid metabolism; protein transport; cholesterol metabolic process; vitamin D metabolic process; cobalamin metabolic process; steroid metabolic process; endocytosis; lipoprotein transport; receptor-mediated endocytosis; high-density lipoprotein particle clearance; transport; in utero embryonic development; thigmotaxis; hyperosmotic response; response to nutrient; adult locomotory behavior; response to bacterium; endocytic hemoglobin import into cell; regulation of locomotion; cobalamin catabolic process; positive regulation of synaptic transmission, glutamatergic; protein homotrimerization;
	Sources:Amigo / QuickGO
Orthologs
	8029
	65969
	ENSG00000107611
	ENSMUSG00000026726
	O60494
	Q9JLB4
	NM_001081
	NM_001081084
	NP_001072
	NP_001074553
	Wikidata
View/Edit Human	View/Edit Mouse

Cubilin is a protein that in humans is encoded by the CUBN gene. It is present upon the luminal surface of enterocytes of the ileum where it facilitates absorption of vitamin B12 by acting as a receptor for IF-cobalamin (intrinsic factor - vitamin B12) complexes, enabling endocytosis of complexes by means of amnionless (AMN).