CSTF2

CSTF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P1T, 2J8P
Identifiers
Aliases	CSTF2, CstF-64, cleavage stimulation factor subunit 2
External IDs	OMIM: 300907; MGI: 1343054; HomoloGene: 80171; GeneCards: CSTF2; OMA:CSTF2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	100,841,520 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	132,987,568 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; oral cavity; ; gonad; ; palpebral conjunctiva; ; mucosa of pharynx; ; testicle; ; ganglionic eminence; ; buccal mucosa cell; ; epithelium of nasopharynx;
	Top expressed in
	ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; lateral septal nucleus; ; dorsal tegmental nucleus; ; anterior amygdaloid area; ; ventral tegmental area; ; arcuate nucleus; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; protein binding; mRNA binding; RNA binding;
Cellular component	mRNA cleavage and polyadenylation specificity factor complex; cleavage body; nucleoplasm; nucleus; nuclear body;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; pre-mRNA cleavage required for polyadenylation; tRNA splicing, via endonucleolytic cleavage and ligation; mRNA polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	1478
	108062
	ENSG00000101811
	ENSMUSG00000031256
	P33240
	Q8BIQ5
	NM_001306206; NM_001306209; NM_001325
	NM_001290398; NM_001290399; NM_133196; NM_001359053; NM_001359054
	NP_001293135; NP_001293138; NP_001316; NP_001293135.1
	NP_001277327; NP_001277328; NP_573459; NP_001345982; NP_001345983
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene,which is located on the X-chromosome in Homo sapiens, but has an autosomal paralog CSTF2T on chromosome 19 coding for the protein CstF64τ.

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.