Casein kinase 2, alpha 1

CSNK2A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JWH, 1NA7, 1PJK, 2PVR, 2ZJW, 3AMY, 3AT2, 3AT3, 3AT4, 3AXW, 3BQC, 3C13, 3FWQ, 3H30, 3JUH, 3MB6, 3MB7, 3NGA, 3NSZ, 3OWJ, 3OWK, 3OWL, 3PE1, 3PE2, 3PE4, 3Q04, 3Q9W, 3Q9X, 3Q9Y, 3Q9Z, 3QA0, 3R0T, 3RPS, 3TAX, 3U4U, 3U87, 3U9C, 3W8L, 3WAR, 3WIK, 3WIL, 3WOW, 4DGL, 4FBX, 4GRB, 4GUB, 4GYW, 4GYY, 4GZ3, 4IB5, 4KWP, 4MD7, 4MD8, 4MD9, 4NH1, 4RLL, 4UB7, 4UBA, 5CQU, 5CQW, 5H8G, 5H8B, 5H8E, 5CLP, 5CSH, 5CVH, 5CS6, 5CU6, 5B0X
Identifiers
Aliases	CSNK2A1, Csnk2a1, Csnk2a1-rs4, CK2A1, CKII, CSNK2A3, casein kinase 2 alpha 1, OCNDS, Cka1, Cka2
External IDs	OMIM: 115440; MGI: 88543; HomoloGene: 90874; GeneCards: CSNK2A1; OMA:CSNK2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	543,835 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,123,772 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; epithelium of colon; ; gingival epithelium; ; Achilles tendon; ; islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; gastrocnemius muscle; ; amniotic fluid;
	Top expressed in
	genital tubercle; ; tail of embryo; ; lumbar spinal ganglion; ; ventricular zone; ; zygote; ; epiblast; ; blastocyst; ; muscle of thigh; ; ganglionic eminence; ; extensor digitorum longus muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; Hsp90 protein binding; protein kinase activity; protein N-terminus binding; protein serine/threonine kinase activity; protein binding; ATP binding; kinase activity; beta-catenin binding; protein phosphatase regulator activity; ribonucleoprotein complex binding; identical protein binding;
Cellular component	NuRD complex; cytosol; Sin3 complex; PcG protein complex; nucleus; nucleoplasm; protein kinase CK2 complex; chromatin; cytoplasm; plasma membrane;
Biological process	chaperone-mediated protein folding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of transcription, DNA-templated; positive regulation of protein catabolic process; phosphorylation; rhythmic process; Wnt signaling pathway; transcription, DNA-templated; positive regulation of Wnt signaling pathway; protein phosphorylation; positive regulation of cell growth; positive regulation of cell population proliferation; cell cycle; signal transduction; apoptotic process; regulation of signal transduction by p53 class mediator; protein folding; phosphatidylcholine biosynthetic process; macroautophagy; peptidyl-threonine phosphorylation; cerebral cortex development; response to testosterone; protein autophosphorylation; liver regeneration; regulation of protein localization to plasma membrane; regulation of chromosome separation; peptidyl-serine phosphorylation; negative regulation of ubiquitin-dependent protein catabolic process; negative regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1457
	12995
	ENSG00000101266
	ENSMUSG00000074698
	P68400; Q5U5J2
	Q60737
	NM_001895; NM_177559; NM_177560; NM_001362770; NM_001362771
	NM_007788
	NP_001886; NP_808227; NP_808228; NP_001349699; NP_001349700
	NP_031814
	Wikidata
View/Edit Human	View/Edit Mouse

Casein kinase II subunit alpha 1 (CK2α) is an enzyme that in humans is encoded by the CSNK2A1 gene, located on chromosome 20.

CK2α is the alpha catalytic subunit of Casein kinase II (CK2). CK2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists in monomeric form and as a tetramer and is composed of two α or α' (alpha prime) subunits and two β subunits; the CK2 holoenzyme has α2β2 stoichiometry. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Three transcript variants encoding two different proteins have been found for this gene. CK2α' paralog is encoded by the CSNK2A2 gene; it differs in the length and sequence of the C-terminus of the protein.