Clusterin

CLU
Identifiers
Aliases	CLU, AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin
External IDs	OMIM: 185430; MGI: 88423; HomoloGene: 1382; GeneCards: CLU; OMA:CLU - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	27,614,700 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	66,218,996 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; Achilles tendon; ; paraflocculus of cerebellum; ; palpebral conjunctiva; ; optic nerve; ; Brodmann area 10; ; right uterine tube; ; middle frontal gyrus; ; Brodmann area 9; ; right testis;
	Top expressed in
	iris; ; ciliary body; ; epithelium of lens; ; habenula; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; Epithelium of choroid plexus; ; dorsal tegmental nucleus; ; subiculum; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	chaperone binding; misfolded protein binding; ATPase activity; protein binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; apical dendrite; cytosol; Golgi apparatus; blood microparticle; mitochondrial membranes; membrane; extracellular matrix; neurofibrillary tangle; chromaffin granule; spherical high-density lipoprotein particle; extracellular region; cell surface; intracellular membrane-bounded organelle; mitochondrion; endoplasmic reticulum; extracellular exosome; platelet alpha granule lumen; nucleus; cytoplasmic vesicle; intracellular anatomical structure; perinuclear region of cytoplasm; extracellular space;
Biological process	apoptotic process; central nervous system myelin maintenance; negative regulation of protein homooligomerization; response to misfolded protein; chaperone-mediated protein complex assembly; positive regulation of tau-protein kinase activity; lipid metabolism; immune system process; negative regulation of amyloid-beta formation; positive regulation of nitric oxide biosynthetic process; complement activation; response to virus; protein stabilization; platelet degranulation; positive regulation of neuron death; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of neurofibrillary tangle assembly; microglial cell activation; protein import; intrinsic apoptotic signaling pathway; positive regulation of amyloid-beta formation; regulation of neuronal signal transduction; microglial cell proliferation; positive regulation of NF-kappaB transcription factor activity; positive regulation of ubiquitin-dependent protein catabolic process; cell morphogenesis; regulation of neuron death; complement activation, classical pathway; positive regulation of tumor necrosis factor production; positive regulation of apoptotic process; regulation of amyloid-beta clearance; innate immune response; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; release of cytochrome c from mitochondria; reverse cholesterol transport; chaperone-mediated protein folding; antimicrobial humoral response; cell death;
	Sources:Amigo / QuickGO
Orthologs
	1191
	12759
	ENSG00000120885
	ENSMUSG00000022037
	P10909
	Q06890
	NM_001831
	NM_013492
	NP_001822
	NP_038520
	Wikidata
View/Edit Human	View/Edit Mouse

Clusterin is a protein that in humans is encoded by the CLU gene on chromosome 8. CLU is an extracellular molecular chaperone which binds to misfolded proteins in body fluids to neutralise their toxicity and mediate their cellular uptake by receptor-mediated endocytosis. Once internalised by cells, complexes between CLU and misfolded proteins are trafficked to lysosomes where they are degraded. CLU is involved in many diseases including neurodegenerative diseases, cancers, inflammatory diseases, and aging.