CLIC1

CLIC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K0M, 1K0N, 1K0O, 1RK4, 3O3T, 3P8W, 3P90, 3QR6, 3SWL, 3TGZ, 3UVH, 4IQA, 4JZQ, 4K0G, 4K0N
Identifiers
Aliases	CLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1
External IDs	OMIM: 602872; MGI: 2148924; HomoloGene: 20343; GeneCards: CLIC1; OMA:CLIC1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,739,763 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,277,725 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; mucosa of transverse colon; ; rectum; ; gallbladder; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; placenta; ; right lung;
	Top expressed in
	corneal stroma; ; granulocyte; ; superior surface of tongue; ; thymus; ; endothelial cell of lymphatic vessel; ; pyloric antrum; ; lip; ; mucous cell of stomach; ; dermis; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated ion channel activity; protein binding; chloride channel activity; cadherin binding; glutathione transferase activity;
Cellular component	cytoplasm; integral component of membrane; vesicle; nuclear membrane; blood microparticle; nuclear envelope; membrane; plasma membrane; chloride channel complex; mitochondrion; brush border; perinuclear region of cytoplasm; extracellular exosome; nucleus; extracellular space;
Biological process	regulation of ion transmembrane transport; ion transport; regulation of cell cycle; regulation of mitochondrial membrane potential; positive regulation of osteoblast differentiation; chloride transport; platelet aggregation; signal transduction; chloride transmembrane transport; glutathione metabolic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	1192
	114584
ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226651; ENSG00000226417;
	ENSG00000230685; ENSG00000206394
	ENSMUSG00000007041
	O00299
	Q9Z1Q5
	NM_001288; NM_001287593; NM_001287594
	NM_033444
	NP_001274522; NP_001274523; NP_001279
	NP_254279
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.

CLIC1 is highly expressed in murine and human microglia, the innate immune cells of the central nervous system. It regulates the motility and ramification of microglial processes, which are essential for continuous surveillance of the brain parenchyma. CLIC1 is also important for the inflammatory potential of microglia by controlling the NLRP3-dependent release of interleukin-1β. Contrary to its name, these functions are not mediated by CLIC1's ion channel activity but depend on its scaffold and enzymatic properties.