CLEC1B

C-type lectin domain family 1 member B (also termed CLEC-1b, C-type lectin-like receptor 2, CLEC-2, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B, CLEC1B, activation-induced C-type lectin, AICL, and 1810061I13Rik) is a cell surface receptor protein. It binds certain biomolecules that act as ligands that when bound to the CLEC-1b expressed by cells stimulates certain functions in these cells. The human CLEC-1b receptor is encoded by the CLEC1B gene which is located on the short (i.e., "p")-arm of chromosome 12 at region 1, band 3, sub-band 1 to sub-band 2 (position notated as 12p13.31-p13.2).<https://www.ncbi.nlm.nih.gov/gene/387836> Most of the recent literature terms the C-type lectin domain family 1 member B as CLEC-2. Since current reports commonly use CLEC-2 rather than CLEC-1b, CLEC-2 will be used here in place of CLEC1b in further describing this protein.

CLEC-2 is a member of the broad family of pattern recognition receptors (i.e., PRRs). Vertebrate PRRs can be classified into five types based on their structural similarities: a) toll-like receptors, b) NOD-like receptors, c) RIG-I-like receptors, d) AIM2 (also termed absent in melanoma 2 or interferon-inducible protein AIM2), and e) C-type lectin receptors (i.e., CLR). CLRs are a superfamily of more than 1,000 proteins. They are subdivided into 17 subgroups. All members of this family possess one or more C-type lectin-like domains, i.e., protein domains that have a characteristic loop-in-a-loop structure formed by their amino acid sequences which form a large loop that encloses a smaller, internal loop or some other type of secondary structure. These internal loops or other structures are formed by two disulfide bridges located at the bases of these loops. CLEC-2 is a C-type lectin receptor.