CIART

CIART
Identifiers
Aliases	CIART, C1orf51, CHRONO, GM129, circadian associated repressor of transcription
External IDs	OMIM: 615782; MGI: 2684975; HomoloGene: 79670; GeneCards: CIART; OMA:CIART - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,287,093 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,789,563 bp
RNA expression pattern
	Top expressed in
	oocyte; ; gastric mucosa; ; skin of abdomen; ; secondary oocyte; ; skin of leg; ; muscle of thigh; ; caudate nucleus; ; gastrocnemius muscle; ; right hemisphere of cerebellum; ; gonad;
	Top expressed in
	neural layer of retina; ; tail of embryo; ; spermatid; ; superior frontal gyrus; ; spermatocyte; ; visual cortex; ; primary visual cortex; ; embryo; ; embryo; ; otolith organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	E-box binding; core promoter sequence-specific DNA binding; protein binding; transcription cis-regulatory region binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	PML body; nucleus;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; circadian regulation of gene expression; transcription, DNA-templated; rhythmic process; locomotor rhythm;
	Sources:Amigo / QuickGO
Orthologs
	148523
	229599
	ENSG00000159208
	ENSMUSG00000038550
	Q8N365
	Q3TQ03
	NM_144697; NM_001300838; NM_001300839; NM_001300840; NM_001300841
	NM_001033302
	NP_001287767; NP_001287768; NP_001287769; NP_001287770; NP_653298
	NP_001028474
	Wikidata
View/Edit Human	View/Edit Mouse

Circadian Associated Repressor of Transcription (also known as Chrono or Gm129) is a protein that in humans is encoded by the CIART gene.

The CIART protein functions as a transcriptional repressor of the BMAL1-CLOCK complex. In addition to negatively regulating the circadian transcription-translation feedback loop (TTFL), the CIART protein is involved with stress metabolism response in response to cortisol. New research implicates that CIART protein and glucocorticoid receptors form a complex and regulate response to stress in a circadian manner.