CHRNG

CHRNG
Identifiers
Aliases	CHRNG, ACHRG, cholinergic receptor nicotinic gamma subunit
External IDs	OMIM: 100730; MGI: 87895; HomoloGene: 3810; GeneCards: CHRNG; OMA:CHRNG - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,548,115 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,140,416 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; cerebellar vermis; ; glutes; ; synovial joint; ; human penis; ; periodontal fiber; ; skeletal muscle tissue; ; sural nerve; ; seminal vesicula;
	Top expressed in
	lens; ; internal carotid artery; ; mylohyoid muscle; ; tongue muscle; ; erector spinae muscles; ; tongue; ; Psoas; ; zygote; ; shoulder; ; psoas major muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	channel activity; acetylcholine binding; acetylcholine receptor activity; ion channel activity; protein binding; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; acetylcholine-gated channel complex; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; neuron projection;
Biological process	muscle contraction; response to nicotine; synaptic transmission, cholinergic; ion transport; cation transmembrane transport; neuromuscular synaptic transmission; signal transduction; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; ion transmembrane transport; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	1146
	11449
	ENSG00000196811
	ENSMUSG00000026253
	P07510
	P04760
	NM_005199
	NM_009604
	NP_005190
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Acetylcholine receptor subunit gamma is a protein that in humans is encoded by the CHRNG gene.

It is one of the subunits that compose the nicotinic acetylcholine receptor (nAChR). It is a pentameric ionotropic receptor composed of five of four different subunits : two alpha (α), one beta (β), one delta (δ) and either one gamma (γ) or one epsilon (ε).

Two forms of AChR are found in mammalian skeletal muscle cells. The mature form, containing the epsilon subunit, which is specific to this mature AChR subtype, is predominant in innervated adult muscle and the embryonic form, containing gamma is present in fetal and denervated muscle.

This switch is mediated by Neuregulin 1 (acetylcholine receptor-inducing activity).