CGP-7930

CGP-7930
Identifiers
	IUPAC name 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol;
CAS Number	57717-80-3;
PubChem CID	5024764;
IUPHAR/BPS	1079;
ChemSpider	4203613 ;
UNII	ZAM4WWA5Y4;
CompTox Dashboard (EPA)	DTXSID90407620 ;
Chemical and physical data
Formula	C19H32O2
Molar mass	292.463 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)c1cc(CC(C)(C)CO)cc(C(C)(C)C)c1O;
	InChI InChI=1S/C19H32O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,20-21H,11-12H2,1-8H3 ; Key:XLWJPQQFJNGUPA-UHFFFAOYSA-N ;
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CGP-7930 was the first positive allosteric modulator of GABA_B receptors described in literature. CGP7930 is also a GABA_A receptor positive allosteric modulator and a blocker of Potassium channels.

CGP7930 was developed in Novartis and has been used extensively for scientific research. It has anxiolytic effects in animal studies, and has a synergistic effect with GABA_B agonists such as baclofen and GHB, as well as reducing self-administration of alcoholic drinks and cocaine.

CNS Review: