CDK5R1

CDK5R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H4L, 1UNG, 1UNH, 1UNL, 3O0G
Identifiers
Aliases	CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1
External IDs	OMIM: 603460; MGI: 101764; HomoloGene: 31200; GeneCards: CDK5R1; OMA:CDK5R1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	32,491,253 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,372,010 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Region I of hippocampus proper; ; Brodmann area 23; ; ventricular zone; ; superior frontal gyrus; ; orbitofrontal cortex; ; Brodmann area 9; ; parietal lobe; ; postcentral gyrus; ; entorhinal cortex;
	Top expressed in
	Rostral migratory stream; ; medial dorsal nucleus; ; medial ganglionic eminence; ; olfactory tubercle; ; nucleus accumbens; ; medial geniculate nucleus; ; prefrontal cortex; ; lateral geniculate nucleus; ; lateral septal nucleus; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; calcium ion binding; ephrin receptor binding; cadherin binding; cyclin-dependent protein serine/threonine kinase activator activity; kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protease binding; actin binding; ionotropic glutamate receptor binding; alpha-tubulin binding; beta-tubulin binding; actin filament binding; protein kinase activator activity;
Cellular component	cytoplasm; cytosol; membrane; postsynaptic density; intracellular membrane-bounded organelle; growth cone; neuromuscular junction; dendritic spine; axon; soma; dendrite; protein kinase 5 complex; perinuclear region of cytoplasm; contractile fiber; nucleus; nucleoplasm; plasma membrane; microtubule; neuron projection; presynapse;
Biological process	positive regulation of protein kinase activity; regulation of neuron differentiation; G protein-coupled acetylcholine receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of actin cytoskeleton organization; embryo development; rhythmic process; ephrin receptor signaling pathway; neuron cell-cell adhesion; regulation of microtubule cytoskeleton organization; neuron migration; cerebellum development; positive regulation of protein serine/threonine kinase activity; positive regulation of neuron apoptotic process; brain development; ionotropic glutamate receptor signaling pathway; layer formation in cerebral cortex; peptidyl-serine phosphorylation; neuron differentiation; cell population proliferation; peptidyl-threonine phosphorylation; negative regulation of transcription, DNA-templated; neuron projection development; cerebral cortex radially oriented cell migration; axonal fasciculation; hippocampus development; negative regulation of axon extension; regulation of dendritic spine morphogenesis; regulation of macroautophagy; superior olivary nucleus maturation; positive regulation of protein targeting to membrane; axon guidance; regulation of signal transduction by p53 class mediator; serine phosphorylation of STAT protein; microtubule cytoskeleton organization; embryo development ending in birth or egg hatching; positive regulation of microtubule polymerization; positive regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of synaptic vesicle cycle; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8851
	12569
	ENSG00000176749
	ENSMUSG00000048895
	Q15078
	P61809
	NM_003885
	NM_009871
	NP_003876
	NP_034001
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.