Membrane cofactor protein

CD46
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
Identifiers
Aliases	CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
External IDs	OMIM: 120920; MGI: 1203290; HomoloGene: 7832; GeneCards: CD46; OMA:CD46 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	207,795,513 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	194,774,557 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; seminal vesicula; ; bronchial epithelial cell; ; jejunal mucosa; ; germinal epithelium; ; parotid gland; ; placenta; ; right uterine tube; ; right lung; ; body of pancreas;
	Top expressed in
	seminiferous tubule; ; spermatid; ; granulocyte; ; vastus lateralis muscle; ; intestinal villus; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; muscle of thigh; ; ventricular zone; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; cadherin binding; protein binding; complement binding; endopeptidase activity; enzyme inhibitor activity; signaling receptor activity;
Cellular component	integral component of membrane; inner acrosomal membrane; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; extracellular exosome; cytoplasmic vesicle; acrosomal vesicle; cytoplasm; Golgi apparatus; basolateral plasma membrane;
Biological process	T cell mediated immunity; adaptive immune response; positive regulation of interleukin-10 production; immune system process; sequestering of extracellular ligand from receptor; positive regulation of regulatory T cell differentiation; negative regulation of gene expression; single fertilization; positive regulation of gene expression; positive regulation of T cell proliferation; positive regulation of memory T cell differentiation; complement activation, classical pathway; positive regulation of transforming growth factor beta production; viral entry into host cell; viral process; regulation of Notch signaling pathway; regulation of complement activation; interleukin-10 production; innate immune response; proteolysis; negative regulation of catalytic activity; negative regulation of complement activation;
	Sources:Amigo / QuickGO
Orthologs
	4179
	17221
	ENSG00000117335
	ENSMUSG00000016493
	P15529
	O88174
NM_002389; NM_153826; NM_172350; NM_172351; NM_172352;
	NM_172353; NM_172354; NM_172355; NM_172356; NM_172357; NM_172358; NM_172359; NM_172360; NM_172361
	NM_010778
NP_002380; NP_722548; NP_758860; NP_758861; NP_758862;
	NP_758863; NP_758869; NP_758871; NP_758865; NP_758866; NP_758867; NP_758868
	NP_034908
	Wikidata
View/Edit Human	View/Edit Mouse

Membrane cofactor protein (MCP), CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.