CBL (gene)

CBL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B47, 1FBV, 1YVH, 2CBL, 2JUJ, 2K4D, 2OO9, 2Y1M, 2Y1N, 3BUM, 3BUN, 3BUO, 3BUW, 3BUX, 3OB1, 3OB2, 3PLF, 4A49, 4A4B, 4A4C, 4GPL
Identifiers
Aliases	CBL, C-CBL2, FRA11B, NSLL, RNF55, Cbl proto-oncogene
External IDs	OMIM: 165360; MGI: 88279; HomoloGene: 3802; GeneCards: CBL; OMA:CBL - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,313,926 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,145,346 bp
RNA expression pattern
	Top expressed in
	gonad; ; trigeminal ganglion; ; testicle; ; trabecular bone; ; saphenous vein; ; spinal ganglia; ; superficial temporal artery; ; nipple; ; blood; ; visceral pleura;
	Top expressed in
	thymus; ; granulocyte; ; Rostral migratory stream; ; spermatocyte; ; tail of embryo; ; spermatid; ; mesenteric lymph nodes; ; lateral septal nucleus; ; anterior amygdaloid area; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; DNA-binding transcription factor activity; phosphotyrosine residue binding; signal transducer activity; metal ion binding; ubiquitin-protein transferase activity; protein binding; ephrin receptor binding; SH3 domain binding; phosphatidylinositol 3-kinase regulatory subunit binding; transferase activity; receptor tyrosine kinase binding; ubiquitin protein ligase activity; cadherin binding; epidermal growth factor receptor binding; protein kinase binding; protein tyrosine kinase binding;
Cellular component	membrane; plasma membrane; nucleus; perinuclear region of cytoplasm; flotillin complex; growth cone; cytoplasm; cytosol; focal adhesion; axon; mast cell granule; membrane raft; Golgi apparatus; cilium; cell projection;
Biological process	positive regulation of receptor-mediated endocytosis; negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; negative regulation of apoptotic process; regulation of signaling; fibroblast growth factor receptor signaling pathway; cell surface receptor signaling pathway; protein ubiquitination; positive regulation of phosphatidylinositol 3-kinase signaling; transforming growth factor beta receptor signaling pathway; cellular response to DNA damage stimulus; cellular response to nerve growth factor stimulus; cellular response to platelet-derived growth factor stimulus; positive regulation of epidermal growth factor receptor signaling pathway; regulation of transcription, DNA-templated; neuron death; cellular response to oxygen-glucose deprivation; response to activity; response to starvation; response to ethanol; protein polyubiquitination; protein monoubiquitination; negative regulation of epidermal growth factor-activated receptor activity; male gonad development; response to gamma radiation; response to testosterone; entry of bacterium into host cell; mast cell degranulation; response to antibiotic; membrane organization; negative regulation of neuron death; cytokine-mediated signaling pathway; interleukin-6-mediated signaling pathway; ubiquitin-dependent protein catabolic process; signal transduction; regulation of Rap protein signal transduction; cellular response to epidermal growth factor stimulus; regulation of platelet-derived growth factor receptor-alpha signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	867
	12402
	ENSG00000110395
	ENSMUSG00000034342
	P22681
	P22682
	NM_005188
	NM_007619
	NP_005179
	NP_031645
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase CBL is an enzyme that is humans is encoded by the CBL (Casitas B-lineage Lymphoma) gene. CBL gene is the founding member the Cbl family. The protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.