Chromosome 3 open reading frame 5 (C3orf52), also known as TTMP or TPA-Induced Transmembrane Protein (accession: NP_078892), is an uncharacterized protein encoded in humans by the C3orf52 gene. C3orf52 (accession: NM_024616) is located on the plus strand of chromosome 3, at gene locus q.13.2 and spans approximately 31,822 base pairs. C3orf52 encodes a transmembrane protein whose predicted function is to act as a membrane -associated regulatory factor in epithelial tissues. Structural features within the protein, including a conserved transmembrane domain, a SEA domain, and extensive glycosylation, suggest a role in protein-protein interactions. Evidence supports that C3orf52 acts as a cofactor for LIPH, facilitating localized lysophosphatidic acid production required for hair follicle morphogenesis. Loss of C3orf52 disrupts this lipid signaling pathway, resulting in autosomal recessive hypotrichosis.