ROS1

ROS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZBF, 4UXL
Identifiers
Aliases	ROS1, MCF3, ROS, c-ros-1, ROS proto-oncogene 1, receptor tyrosine kinase
External IDs	OMIM: 165020; MGI: 97999; HomoloGene: 2207; GeneCards: ROS1; OMA:ROS1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	117,425,942 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	52,071,340 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; corpus epididymis; ; right lung; ; lower lobe of lung; ; testicle; ; muscle of thigh; ; visceral pleura; ; decidua; ; caput epididymis; ; Brodmann area 9;
	Top expressed in
	semen; ; epithelium of small intestine; ; ileum; ; duodenum; ; precursor cell; ; lumbar subsegment of spinal cord; ; migratory enteric neural crest cell; ; spermatid; ; submandibular gland; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; protein phosphatase binding; ATP binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; cell surface; perinuclear region of cytoplasm; cytoplasm; integral component of plasma membrane; receptor complex;
Biological process	cell differentiation; regulation of TOR signaling; signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of phosphate transport; negative regulation of gene expression; protein phosphorylation; spermatogenesis; regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine autophosphorylation; cell population proliferation; columnar/cuboidal epithelial cell development; regulation of cell growth; negative regulation of signal transduction; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	6098
	19886
	ENSG00000047936
	ENSMUSG00000019893
	P08922
	Q78DX7
	NM_002944; NM_001378891; NM_001378902
	NM_011282
	NP_002935; NP_001365820; NP_001365831
	NP_035412
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.

This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.